Funded Biomarker Testing
69 items
Reflex testing on newly diagnosed adult cases of Ependymoma (infratentorial).
Funded Biomarker Disease Site: Central Nervous System (CNS)
Biomarker: EZHIP, H3 K27me3
Testing Method:Immunohistochemistry (IHC)
Testing Site: Hospital for Sick Children (SickKids)
Reflex testing on newly diagnosed adult cases of Ependymoma (supratentorial).
Funded Biomarker Disease Site: Central Nervous System (CNS)
Biomarker: ZFTA, YAP1, CDK2NA
Testing Method:Fluoroscence In Situ Hybridization (FISH), Nanostring, RNA Sequence Panel
Testing Site: Trillium Health Partners
Reflex testing on newly diagnosed adult cases of medulloblastoma.
Funded Biomarker Disease Site: Central Nervous System (CNS)
Biomarker: CTNNB1, INI1/SMARCB1, FLNA, P53*, Nanostring/Methylation for subtyping
Testing Method:Immunohistochemistry (IHC), Nanostring
Testing Site: Hospital for Sick Children (SickKids)
Reflex testing on newly diagnosed cases advanced*/metastatic colorectal or small bowel carcinoma.
Funded Biomarker Disease Site: Colorectal, Small Bowel
Biomarker: BRAF, KRAS, NRAS, PIK3CA
Optional for 21/22: PTEN
Testing Method:Panel
Testing Site: Hamilton Health Sciences, Health Sciences North, Kingston Health Sciences Centre, London Health Sciences Centre, Mount Sinai Hospital, St. Joseph's Healthcare Hamilton, Sunnybrook Health Sciences Centre, The Ottawa Hospital, Trillium Health Partners, University Health Network, William Osler Health System
Reflex testing on newly diagnosed cases of advanced*/metastatic melanoma.
Funded Biomarker Disease Site: Melanoma
Biomarker: BRAF, KIT, NRAS
Testing Method:Panel
Testing Site: Hamilton Health Sciences, Health Sciences North, Kingston Health Sciences Centre, London Health Sciences Centre, Mount Sinai Hospital, St. Joseph's Healthcare Hamilton, Sunnybrook Health Sciences Centre, The Ottawa Hospital, Trillium Health Partners, University Health Network, William Osler Health System
Reflex testing on newly diagnosed cases of NSCLC (adenocarcinoma/non-squamous).
Funded Biomarker Disease Site: Lung
Biomarker: PD-L1, ALK, EGFR, ROS1, BRAF, MET (Met Skipping), RET, FGFR1, HER2 (ERBB2), KRAS, PIK3CA, NTRK1, NTRK2, NTRK3
Optional for 22/23: NRG1, TP53, STK11, KEAP1
Testing Method:Panel
Testing Site: Hamilton Health Sciences, Health Sciences North, Kingston Health Sciences Centre, London Health Sciences Centre, St. Joseph's Healthcare Hamilton, Sunnybrook Health Sciences Centre, The Ottawa Hospital, Trillium Health Partners, University Health Network, William Osler Health System
Reflex testing on newly diagnosed cases of NSCLC (squamous).
Funded Biomarker Disease Site: Lung
Biomarker: PD-L1
Testing Method:Immunohistochemistry (IHC)
Testing Site: Hamilton Health Sciences, Health Sciences North, Kingston Health Sciences Centre, London Health Sciences Centre, St. Joseph's Healthcare Hamilton, Sunnybrook Health Sciences Centre, The Ottawa Hospital, Trillium Health Partners, University Health Network, William Osler Health System
Reflex testing on newly diagnosed CD117 (cKIT) positive Gastrointestinal Stromal Tumours
Funded Biomarker Disease Site: Soft Tissue
Biomarker: BRAF, KIT, PDGFRA (Optional 23/24 - SDH, NTRK (fusion))
Testing Method:Sequencing
Testing Site: Hamilton Health Sciences, London Health Sciences Centre, Mount Sinai Hospital, St. Joseph's Healthcare Hamilton, Sunnybrook Health Sciences Centre, The Ottawa Hospital, University Health Network
Reflex testing on newly diagnosed CD117 (cKIT) positive Gastrointestinal Stromal Tumours
Funded Biomarker Disease Site: Soft Tissue
Biomarker: SDHB
Testing Method:Immunohistochemistry (IHC)
Testing Site: London Health Sciences Centre, Mount Sinai Hospital
Reflex testing on newly diagnosed epithelial and low malignant potential ovarian tumours.
Funded Biomarker Disease Site: Ovary
Biomarker: MLH1, MSH2, MSH6, PMS2
Testing Method:Immunohistochemistry (IHC)
Testing Site: Hamilton Health Sciences, Health Sciences North, Kingston Health Sciences Centre, London Health Sciences Centre, Markham Stouffville Hospital (Oak Valley Health), Mount Sinai Hospital, St. Joseph's Healthcare Hamilton, Sunnybrook Health Sciences Centre, The Ottawa Hospital, Trillium Health Partners, Unity Health - St. Michael's Hospital, University Health Network, William Osler Health System
Reflex testing on newly diagnosed gastric tumours when EBV associated adenocarcinoma is being considered.
Funded Biomarker Disease Site: Stomach
Biomarker: EBER
Testing Method:In Situ Hybridization (ISH)
Testing Site: Hamilton Health Sciences, Health Sciences North, Kingston Health Sciences Centre, London Health Sciences Centre, Markham Stouffville Hospital (Oak Valley Health), Mount Sinai Hospital, St. Joseph's Healthcare Hamilton, Sunnybrook Health Sciences Centre, The Ottawa Hospital, Trillium Health Partners, Unity Health - St. Michael's Hospital, University Health Network, William Osler Health System
Reflex testing on newly diagnosed invasive gastroesophageal adenocarcinomas.
Funded Biomarker Disease Site: Esophagus, Stomach
Biomarker: MLH1, MSH2, MSH6, PMS2, HER2
Testing Method:Immunohistochemistry (IHC)
Testing Site: Hamilton Health Sciences, Health Sciences North, Kingston Health Sciences Centre, London Health Sciences Centre, Mount Sinai Hospital, St. Joseph's Healthcare Hamilton, Sunnybrook Health Sciences Centre, The Ottawa Hospital, Unity Health - St. Michael's Hospital, University Health Network, William Osler Health System