Primary Treatment for Locally Advanced Cervical Cancer: Concurrent Platinum-Based Chemotherapy and Radiation

Patient Population

Women with cervical cancer for whom primary treatment with radiotherapy is being considered:

• Those with locally advanced cervical cancer
• Those with bulky clinical stage IB (>4 cm) cervical cancer, who are treated with radiotherapy
• Those with high-risk early-stage cervical cancer (node-positive or margin-positive), who will be treated with radiotherapy following hysterectomy

Research Question(s)

For women with cervical cancer in whom radiotherapy is considered appropriate, does the addition of concurrent platinum-based chemotherapy improve survival and quality of life with acceptable toxicity?