Published Research
A large body of research has been produced by scientists, clinical leads, scientific leads and/or staff working for or funded by Cancer Care Ontario. Much of the research has been published in peer-reviewed scientific journals.
For a list of research from across CCO, including articles about chronic kidney disease and other health related topics, visit PubMedOpens.
Featured Cancer Research Articles
Del Paggio JC, Naipaul R, Gavura S, Mercer RE, Koven R, Gyawali B, Wilson BE, Booth CM. Cost and value of cancer medicines in a single-payer public health system in Ontario, Canada: a cross-sectional study. Lancet Oncol. 2024 Apr;25(4):431-438. doi: 10.1016/S1470-2045(24)00072-X. PMID: 38547890.
Guan Q, Aktar SJ, Pataky RE, Stephen MM, Marques M, Gambaro K, Rachedi K, Forster K, Strub S, Stock D, de Léséleuc L, Cheung WY, Peacock S, Farrer C, Gavura S, Tadrous M, Grant RC, Chan KKW. Real-World Safety of Niraparib for Maintenance Treatment of Ovarian Cancer in Canada. Curr Oncol. 2024 Jun 19;31(6):3591-3602. doi: 10.3390/curroncol31060264. PMID: 38920747.
Law CCY, Zhang L, Carvalho AL, Rabeneck L, Barkun AN, Nied-Kutterer A, Armstrong D, Wong CK, Lamothe D, MacIntosh D, Dubé C, Kilfoil E, Telford J, Baxter NN, Kumar E, Singh H, McGrath J, Coulter L, Sadowski D, Efthimiou K, DuPlessis H, Bunzeluk K, Gentile L, Guertin MH, McCurdy BR, Kohle M, Stewart M, Stimpson R, Antle S, Polos S, Heitman SJ, Zhu T, Ebenuwah S, Kosloski J, Mok M, Basu P, Tinmouth J. Canadian colorectal cancer screening programs: How do they measure up using the International Agency for Research on Cancer criteria for organized screening? J Can Assoc Gastroenterol. 2024 Aug;7(4):312-318. doi: 10.1093/jcag/gwae015. PMID: 39139223.
Lu B, Dvorani E, Nguyen L, Beca JM, Mercer RE, Adamic A, Muñoz C, Chan KKW. Cost-effectiveness analysis of bevacizumab biosimilars versus originator bevacizumab for metastatic colorectal cancer: a comparative study using real-world data. Value Health. 2024 Aug 8:S1098-3015(24)02801-8. doi: 10.1016/j.jval.2024.07.018. Epub ahead of print. PMID: 39127249.
Muñoz C, Tai X, Arias J, Eisen A, Chaudhry M, Gavura S, Chan KKW. Comparative Effectiveness and Safety of Trastuzumab Biosimilars to Herceptin for Adjuvant Treatment of HER2+ Breast Cancer. Curr Oncol. 2024 Mar 21;31(3):1633-1644. doi: 10.3390/curroncol31030124. PMID: 38534957.
Nicolau IA, Moineddin R, Brooks JD, Antoniou T, Gillis JL, Kendall CE, Cooper C, Cotterchio M, Salters K, Smieja M, Kroch AE, Price C, Mohamed A, Burchell AN. Associations of CD4 Cell Count Measures With Infection-Related and Infection-Unrelated Cancer Risk Among People With HIV. J Acquir Immune Defic Syndr. 2024 Aug 15;96(5):447-456. doi: 10.1097/QAI.0000000000003452. PMID: 38985442.
O'Grady JR, Ferdus J, Leylachian S, Bolarinwa Y, Wagamese J, Ellison LK, Siedule C, Batista R, Sheppard AJ. Lung cancer in First Nations, Inuit, and Métis peoples in Canada - a scoping review. Int J Circumpolar Health. 2024 Dec;83(1):2381879. doi: 10.1080/22423982.2024.2381879. Epub 2024 Jul 29. PMID: 39074244
Samsel K, Navaneelan T, DeBono N, Everest L, Demers PA, Sritharan J. Leukemia Incidence by Occupation and Industry: A Cohort Study of 2.3 Million Workers from Ontario, Canada. Int J Environ Res Public Health. 2024 Jul 27;21(8):981. doi: 10.3390/ijerph21080981. PMID: 39200592.
Sritharan J, Arrandale VH, Kirkham TL, Dakouo M, MacLeod JS, Demers PA. Risk of chronic obstructive pulmonary disease in a large cohort of Ontario, Canada workers. Sci Rep. 2024 Apr 16;14(1):8756. doi: 10.1038/s41598-024-59429-1. PMID: 38627517.
Takhar P, Geirnaert M, Gavura S, Beca J, Mercer RE, Denburg A, Muñoz C, Tadrous M, Parmar A, Dionne F, Boehm D, Chambers C, Craig E, Trudeau M, Cheung MC, Houlihan J, McDonald V, Pechlivanoglou P, Taylor M, Wasylenko E, Wranik WD, Chan KKW. Application of Multi-Criteria Decision Analysis (MCDA) to Prioritize Real-World Evidence Studies for Health Technology Management: Outcomes and Lessons Learned by the Canadian Real-World Evidence for Value of Cancer Drugs (CanREValue) Collaboration. Curr Oncol. 2024 Apr 1;31(4):1876-1898. doi: 10.3390/curroncol31040141. PMID: 38668044.
Tammemägi MC, Darling GE, Schmidt H, Walker MJ, Langer D, Leung YW, Nguyen K, Miller B, Llovet D, Evans WK, Buchanan DN, Espino-Hernandez G, Aslam U, Sheppard A, Lofters A, McInnis M, Dobranowski J, Habbous S, Finley C, Luettschwager M, Cameron E, Bravo C, Banaszewska A, Creighton-Taylor K, Fernandes B, Gao J, Lee A, Lee V, Pylypenko B, Yu M, Svara E, Kaushal S, MacNiven L, McGarry C, Della Mora L, Koen L, Moffatt J, Rey M, Yurcan M, Bourne L, Bromfield G, Coulson M, Truscott R, Rabeneck L. Risk-based lung cancer screening performance in a universal healthcare setting. Nat Med. 2024 Apr;30(4):1054-1064. doi: 10.1038/s41591-024-02904-z. Epub 2024 Apr 19. PMID: 38641742.
Tinmouth J, Chen B, Niu Y, Silveira K, Rabeneck L, Dubé C; Cancer Control and Evidence Integration PCCRC Method Working Group, Ontario Health, Cancer Control. Measuring post-colonoscopy colorectal cancers: Variations in methodology to address indicator timeliness and use in high-risk populations. Gastroenterology. 2024 Aug;167(3):608-610.e2. doi: 10.1053/j.gastro.2024.04.014. Epub 2024 Apr 25. PMID: 38670285. [Working group members: Julia Gao, Yingzi Li, Andrea Hatvani, Bronwen R McCurdy, Jocelyn Sacco, Tina Karapetyan]
Verville L, McKay C, Kouroukis T, Apostolovski S, Sabloff M, Buckstein R, Kennedy K, Yee K, Eakins A, Bredeson C. Developing Organizational Requirements to Standardize Delivery and Improve Quality of Acute Leukemia Care in Ontario. Curr Oncol. 2024 Aug 15;31(8):4656-4674. doi: 10.3390/curroncol31080347. PMID: 39195330
Walker MJ, Blackmore KM, Chang A, Lambert-Côté L, Turgeon A, Antoniou AC, Bell KA, Broeders MJ, Brooks JD, Carver T, Chiquette J, Després P, Easton DF, Eisen A, Eloy L, Evans DG, Fienberg S, Joly J, Kim RH, Kim SJ, Knoppers BM, Lofters AK, Nabi H, Paquette JS, Pashayan N, Sheppard AJ, Stockley TL, Dorval M, Simard J, Chiarelli AM. Implementing Multifactorial Risk Assessment with Polygenic Risk Scores for Personalized Breast Cancer Screening in the Population Setting: Challenges and Opportunities. Cancers (Basel). 2024 Jun;16(11):2116. doi: 10.3390/cancers16112116. PMID: 38893236
Wesselink E, Gauderman W, Berndt SI, Brenner H, Buchanan DD, Campbell PT, Chan AT, Chang-Claude J, Cotterchio M, Gunter MJ, Hoffmeister M, Joshi AD, Newton CC, Pai RK, Pellatt AJ, Phipps AI, Song M, Um CY, van Guelpen B, White E, Peters U, van Duijnhoven FJB. Calcium intake and genetic variants in the calcium sensing receptor in relation to colorectal cancer mortality: an international consortium study of 18,952 patients. BJC Rep. 2024;2(1):63. doi: 10.1038/s44276-024-00077-3. Epub 2024 Sep 2. PMID: 39233917.
Articles by external researchers utilizing Cancer Care Ontario data
Gupta A, Nguyen P, Kain D, Robinson AG, Kulkarni AA, Johnson DH, Presley CJ, Blaes AH, Rocque GB, Ganguli I, Booth CM, Hanna TP. Trajectories of Health Care Contact Days for Patients With Stage IV Non-Small Cell Lung Cancer. JAMA Netw Open. 2024 Apr 1;7(4):e244278. doi: 10.1001/jamanetworkopen.2024.4278. PMID: 38587847.
Le Provost B, Parent MÉ, Villeneuve PJ, Waddingham CM, Brook JR, Lavigne E, Dugandzic R, Harris SA. Residential exposure to ambient fine particulate matter (PM2.5) and nitrogen dioxide (NO2) and incident breast cancer among young women in Ontario, Canada. Cancer Epidemiol. 2024 Oct;92:102606. doi: 10.1016/j.canep.2024.102606. Epub 2024 Jul 9. PMID: 38986354.
Lofters AK, Sammott SA, Swayze S, Bender JL, Alibhai SMH, Henry A, Noel K, Datta G. Stage of diagnosis and survival for prostate cancer among immigrant men in Ontario, Canada. Cancer Epidemiol. 2024 Jun;90:102562. doi: 10.1016/j.canep.2024.102562. Epub 2024 Mar 21. PMID: 38513543.
Motamedi N, McClure A, Power NE, Pautler S, Given L, Welk B, McGee J. The impact of the Ontario quality-based procedures funding model on radical prostatectomy outcomes. Can Urol Assoc J. 2024 Sep;18(9):E269-E275. doi: 10.5489/cuaj.8632. PMID: 39190172.
Nathoo A, Brogly SB, Velez MP. Pregnancy outcomes in survivors of adolescent and young adult breast cancer: a population-based cohort study. J Obstet Gynaecol Can. 2024 Aug 16:102638. doi: 10.1016/j.jogc.2024.102638. Epub ahead of print. PMID: 39154661.
Ruco A, Lofters AK, Lu H, Baxter NN, Guilcher S, Kopp A, Vahabi M, Datta GD. Lung cancer survival by immigrant status: a population-based retrospective cohort study in Ontario, Canada. BMC Cancer. 2024 Sep 7;24(1):1114. doi: 10.1186/s12885-024-12804-7. PMID: 39243029.
Shuldiner J, Sutradhar R, Lau C, Shah N, Lam E, Ivers N, Nathan PC. Longitudinal adherence to surveillance for late effects of cancer treatment: a population-based study of adult survivors of childhood cancer. CMAJ. 2024 Mar 10;196(9):E282-E294. doi: 10.1503/cmaj.231358. PMID: 38467416.
Sussman J, Cerasuolo JO, Pond GR, Bainbridge D, Seow H. Patterns of Survivorship Follow-Up Care Among Patients With Breast Cancer: A Retrospective Population-Based Cohort Study in Ontario, Canada, Between 2006 and 2016. JCO Oncol Pract. 2024 Jul 25:OP2300813. doi: 10.1200/OP.23.00813. Epub ahead of print. PMID: 39052954.
Walsh R, Lofters A, Groome P, Moineddin R, Krzyzanowska M, Griffiths R, Grunfeld E. Wait times and breast cancer survival: a population-based retrospective cohort study using CanIMPACT data. Cancer Causes Control. 2024 Sep;35(9):1245-1257. doi: 10.1007/s10552-024-01879-z. Epub 2024 May 15. PMID: 38748276.
Worthington J, Sun Z, Fu R, Lew JB, Chan KKW, Li Q, Eskander A, Hui H, McLoughlin K, Caruana M, Peacock S, Yong JHE, Canfell K, Feletto E, Malagón T. COVID-related disruptions to colorectal cancer screening, diagnosis, and treatment could increase cancer burden in Australia and Canada: A modelling study. PLoS One. 2024 Apr 1;19(4):e0296945. doi: 10.1371/journal.pone.0296945. PMID: 38557758.
Yee EK, Hallet J, Look Hong NJ, Nguyen L, Coburn N, Wright FC, Gandhi S, Jerzak KJ, Eisen A, Roberts A. Impact of Location of Residence and Distance to Cancer Centre on Medical Oncology Consultation and Neoadjuvant Chemotherapy for Triple-Negative and HER2-Positive Breast Cancer. Curr Oncol. 2024 Aug 20;31(8):4728-4745. doi: 10.3390/curroncol31080353. PMID: 39195336.