Drug Safety & Information
These documents for healthcare providers offer information about drug safety, administration and best practices.
Recommendations
Use the links in this list to view selected recommendations and clinical tools related to systemic treatment. For a full list of evidence-based chemotherapy guidance available on this website, go to chemotherapy guidelines & advice.
- Fluoropyrimidine Treatment in Patients with Dihydropyrimidine Dehydrogenase (DPD) Deficiency: Guidance for Clinicians
- Hepatitis B Virus Screening and Management for Patients Receiving Systemic Treatment
- Enhancing the Delivery of Oncology Systemic Treatment in the Home and Community in Ontario Recommendations Report
- Prevention and Outpatient Management of Febrile Neutropenia in Adult Cancer Patients: Clinical Practice Guideline
- Management of Cancer Medication-Related Infusion Reactions
- Position Statements for the Implementation of Oncology Biosimilars
- 2019 Antiemetic Recommendations for Chemotherapy-Induced Nausea and Vomiting: A Clinical Practice Guideline
- Immune Checkpoint Inhibitor Toxicity Management Clinical Practice Guideline
- 2018 CCO Beyond-Use Date Recommendations Report
- 2017 Safe Use and Handling of Oral Anti-Cancer Drugs (OACDs) in Community Pharmacy: A Pan-Canadian Consensus Guideline
- Best Practice Recommendations for Regimen Development and Maintenance
- Recommended Criteria of a Pre-printed Order (PPO): Oral Chemotherapy Take-home Prescriptions
- Clinical Verification of Cancer Drug Prescriptions Checklist: Cancer Centres and Specialty Pharmacies
- Enhancing Delivery for Take-Home Cancer Drugs
- Safe Handling of Cytotoxics
- Safe Administration of Chemotherapy: Safety During Chemotherapy Ordering, Transcribing, Dispensing, and Patient Identification
- Safe Administration of Systemic Cancer Therapy: Administration of Chemotherapy and Management of Preventable Adverse Event
- 2016 Systemic Treatment Computerized Prescriber Order Entry (ST CPOE): Best Practice Guideline for Intravenous and Oral Chemotherapy
- 2012 Computerized Prescriber Order Entry (CPOE) in the Outpatient Oncology Setting
- Dose Modification - Provides dosage modification recommendations for hematologic and non-hematologic toxicities.
- Management of Angiogenesis Inhibitor (AI)-Induced Hypertension
Safety Reminders
- Subcutaneous Rituximab Formulation Safety Considerations
- Kadcyla® Trastuzumab Emtansine Safety Reminder
Calculations
- Body Surface Area Calculation: Position Statement - Addresses the use of height and weight in the best equation to calculate body surface area in order to minimize calculation errors.
- Creatinine Clearance Calculation - Outlines the calculation of estimated creatinine clearance.